反应详情

The title compound was prepared from methyl 6-(2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)oxazol-5-yl)picolinate (70 mg, 0.138 mmol) following General Procedure C. Flash chromatography (10-30% EtOAc) yielded the title compound as a white solid (19 mg, 35%): 1H NMR (CDCl3, 500 MHz) δ 8.19 (d, 1H, J=7.0 Hz), 8.12-8.09 (m, 2H), 8.06-8.03 (m, 1H), 7.36-7.33 (m, 2H), 7.26-7.24 (m, 3H), 4.11 (s, 3H), 3.19 (t, 2H, J=7.0 Hz), 2.69 (t, 2H, J=7.5 Hz), 1.89-1.83 (m, 2H), 1.75-1.69 (m, 2H), 1.55-1.47 (m, 4H); 13C NMR (CDCl3, 125 MHz) δ 188.9, 165.5, 158.0, 152.7, 149.0, 147.0, 143.1, 138.7, 128.8, 128.7, 128.4, 126.0, 125.6, 123.7, 53.5, 39.6, 36.3, 31.7, 29.4, 29.4, 24.3; MALDI-FTMS m/z 393.1796 (M+H+, C23H25N2O4, requires 393.1809).