N-BOC-4-(phenylethynyl)piperidine → 4-(Phenylethynyl)piperidine hydrochloride

HRID 605809Notes

Reaction equation

HRID 605809 reaction equation
[C:1]1([C:7]#[C:8][CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22].CCOC(C)=O>>[ClH:22].[C:1]1([C:7]#[C:8][CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 17986993N-BOC-4-(phenylethynyl)piperidineHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 574218404-(Phenylethynyl)piperidine hydrochloride

Procedure

4 M hydrogen chloride/EtOAc solution (70 ml) was added to tert-butyl 4-(phenylethynyl)piperidine-1-carboxylate (7.0 g), followed by stirring at room temperature for 30 minutes. The solvent was evaporated to obtain 4-(phenylethynyl)piperidine hydrochloride (5.4 g) as a white powder.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-6d6bf6f8b894423fb875bbb3af863f42
Source dataset
uspto-grants-2011_03
Patent number
US07915261B2

Reaction notes

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