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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 605809Generated: October 30, 2026

N-BOC-4-(phenylethynyl)piperidine → 4-(Phenylethynyl)piperidine hydrochloride

https://huagongshe.com/reaction/605809

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-BOC-4-(phenylethynyl)piperidineHCID 17986993—
ReactantHydrogen chloride-ethyl acetateHCID 21866389—
Product4-(Phenylethynyl)piperidine hydrochlorideHCID 57421840—

Reaction Steps

4 M hydrogen chloride/EtOAc solution (70 ml) was added to tert-butyl 4-(phenylethynyl)piperidine-1-carboxylate (7.0 g), followed by stirring at room temperature for 30 minutes. The solvent was evaporated to obtain 4-(phenylethynyl)piperidine hydrochloride (5.4 g) as a white powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07915261B2
Source datasetuspto-grants-2011_03
ORD IDord-6d6bf6f8b894423fb875bbb3af863f42
Source noteuspto-grants-2011_03