Hydrogen chloride-ethyl acetate → HCID 57507789, compound

HRID 605818Notes

Reaction equation

HRID 605818 reaction equation
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:24].CCOC(C)=O>C1COCC1>[ClH:24].[ClH:24].[NH2:8][CH:9]1[CH2:10][CH2:11][N:12]([C:15]([O:17][C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)=[O:16])[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57507788HCID 57507788, compound

Product 1

HCID 57507789HCID 57507789, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Pyridin-3-yl 4-[(tert-butoxycarbonyl)amino]piperidine-1-carboxylate (0.249 g) was dissolved in THF (5.0 ml), and under ice cooling, 4 M hydrogen chloride/EtOAc solution (2.10 ml) was added thereto, followed by stirring at room temperature for 24 hours. The reaction solution was concentrated to dryness to obtain pyridin-3-yl 4-aminopiperidine-1-carboxylate dihydrochloride (0.280 g).

Workup

  1. concentrationThe reaction solution was concentrated to dryness

Sources & evidence

ORD record
ord-8df03d9d1f0b48ce8df5d247d7e07772
Source dataset
uspto-grants-2011_03
Patent number
US07915261B2

Reaction notes

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