Hydrogen chloride-ethyl acetate → 2-Methyl-6-[4-(2-piperidin-4-ylethyl)piperidin-1-yl]pyridine dihydrochloride

HRID 605835Notes

Reaction equation

HRID 605835 reaction equation
[ClH:1].CCOC(C)=O.[CH3:8][C:9]1[N:14]=[C:13]([N:15]2[CH2:20][CH2:19][CH:18]([CH2:21][CH2:22][CH:23]3[CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH2:24]3)[CH2:17][CH2:16]2)[CH:12]=[CH:11][CH:10]=1>CCOC(C)=O>[ClH:1].[ClH:1].[CH3:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]([N:15]2[CH2:20][CH2:19][CH:18]([CH2:21][CH2:22][CH:23]3[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[CH2:17][CH2:16]2)[N:14]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 57507817Tert-butyl 4-{2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl}piperidine-1-carboxylate

Product 1

HCID 575078182-Methyl-6-[4-(2-piperidin-4-ylethyl)piperidin-1-yl]pyridine dihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 4 M hydrogen chloride/EtOAc solution (2 ml) was added to an EtOAc (10 ml) solution of tert-butyl 4-{2-[1-(6-methylpyridin-2-yl)piperidin-4-yl]ethyl}piperidine-1-carboxylate (650 mg), followed by stirring at room temperature for 2 days. The reaction liquid was concentrated to obtain 2-methyl-6-[4-(2-piperidin-4-ylethyl)piperidin-1-yl]pyridine dihydrochloride (644 mg) as a yellow amorphous substance.

Workup

  1. customThe reaction liquid
  2. concentrationwas concentrated

Sources & evidence

ORD record
ord-d78be6eeeca6446eacc0c6450800963e
Source dataset
uspto-grants-2011_03
Patent number
US07915261B2

Reaction notes

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