反应详情

温度

0 °C

(compound known, e.g. WO 2003/032994) Potassium thiocyanate (0.97 g, 10 mM) was added to a solution of 2,4-dichloro-5-nitropyrimidine (1.94 g 10, mM) in EtOH (40 mL) cooled to 0° C. via an ice bath. The solution was stirred at 0° C. for 30 min, then the bath was removed and the resulting suspension allowed to come to RT over 60 min, when water (100 mL) was added. The precipitate was collected via filtration, washed with ice cold water, dissolved with DCM, dried (MgSO4), filtered and evaporated to yield the titled compound (1.7 g).

1. customthe bath was removed
2. waitto come to RT over 60 min
3. additionwhen water (100 mL) was added
4. filtrationThe precipitate was collected via filtration
5. washwashed with ice cold water
6. dissolutiondissolved with DCM
7. dry with materialdried (MgSO4)
8. filtrationfiltered
9. customevaporated