HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 4-Bromo-N-methyl-2-thiazolecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Ethyl 4-bromothiazole-2-carboxylate | HCID 49757955 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Bromo-N-methyl-2-thiazolecarboxamide | HCID 57590086 | — |
Reaction Steps
4-Bromothiazole-2-carboxylic acid ethyl ester (500 mg, 2.13 mmol) is dissolved in methanol (1 mL) and methyl amine in methanol (10 mL) is added. The mixture is stirred overnight at room temperature. Evaporation of the solvent under reduced pressure affords the title compound as yellow solid. LCMS: Rt 0.92 min (100%) m/z (ESI) 219/221 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915256B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-1ac158033ba34f7089024cf60db846ad |
| Source note | uspto-grants-2011_03 |