Methylamine → 4-Bromo-N-methyl-2-thiazolecarboxamide

HRID 605945Notes

Reaction equation

HRID 605945 reaction equation
C([O:3][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=O)C.[CH3:12][NH2:13]>CO>[CH3:12][NH:13][C:4]([C:6]1[S:7][CH:8]=[C:9]([Br:11])[N:10]=1)=[O:3]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 49757955Ethyl 4-bromothiazole-2-carboxylate

Product 1

HCID 575900864-Bromo-N-methyl-2-thiazolecarboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

4-Bromothiazole-2-carboxylic acid ethyl ester (500 mg, 2.13 mmol) is dissolved in methanol (1 mL) and methyl amine in methanol (10 mL) is added. The mixture is stirred overnight at room temperature. Evaporation of the solvent under reduced pressure affords the title compound as yellow solid. LCMS: Rt 0.92 min (100%) m/z (ESI) 219/221 (M+H)+.

Workup

  1. customEvaporation of the solvent under reduced pressure

Sources & evidence

ORD record
ord-1ac158033ba34f7089024cf60db846ad
Source dataset
uspto-grants-2011_03
Patent number
US07915256B2

Reaction notes

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