反应详情

This compound may be prepared using methods as described for Compound 6, step 4 using 4-(5-bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-N-pyridin-3-ylmethyl-benzamide (100 mg, 0.24 mmol), 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (93 mg, 0.48 mmol) and Pd(PPh3)4 (70 mg, 0.06 mmol) in 1.5M K2CO3 (aq) (1.4 mL) and dioxane (2.5 mL). The crude material is purified by silica gel column chromatography eluting with DCM followed by 98:2 then 96:4 then 90:10 DCM:NH3 (7M in MeOH) to afford the title compound as a white solid (19.6 mg, 20%).

1. customThis compound may be prepared
2. customThe crude material is purified by silica gel column chromatography
3. washeluting with DCM