2-Bromo-2'-acetonaphthone → HCID 56697580, compound

HRID 606006Notes

Reaction equation

HRID 606006 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=1)=O.[NH2:15][C:16]1[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][N:17]=1.C(=O)([O-])O.[Na+]>>[Br:22][C:19]1[CH:20]=[CH:21][C:16]2[N:17]([CH:2]=[C:3]([C:5]3[CH:14]=[CH:13][C:12]4[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=4)[CH:6]=3)[N:15]=2)[CH:18]=1

Participants

4

Reactant 3

HCID 691792-Bromo-2'-acetonaphthoneHCID 706222-Amino-5-bromopyridineHCID 516892Sodium Bicarbonate

Product 1

HCID 56697580HCID 56697580, compoundYield 127.9%

Procedure

By carrying out the process as in Example 1, and starting from 0.5 g of 2-bromo-1-(naphthalen-2-yl)ethanone, 0.72 g of 2-amino-5-bromopyridine and 0.29 g of sodium hydrogen carbonate, 0.83 g of 6-bromo-2-(naphthalen-2-yl)imidazo[1,2-a]pyridine is obtained. Mp=226-228° C.

Sources & evidence

ORD record
ord-c8a9f1911161488ea9d1d1e6f5bd4812
Source dataset
uspto-grants-2011_03
Patent number
US07915284B2

Reaction notes

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