反应详情

300 mg of 6-bromo-2-(4-chlorophenyl)imidazo[1,2-a]pyridine (prepared as described in 5.1), 240 mg of 3-acetylboronic acid and 34 mg of tetrakis(triphenylphosphine)palladium are mixed in a microwave tube containing 4.5 ml of acetonitrile, 4.5 ml of toluene and 4.5 ml of a 2M solution of sodium hydrogen carbonate. The tube is placed in a microwave apparatus and irradiated at 150° C. for 15 min. The organic phase is separated, dried and concentrated under reduced pressure. A solid residue is obtained which is triturated in a mixture of 3 ml of dichloromethane and 3 ml of diisopropyl ether for 30 min. The precipitate is recovered by filtration, washed with diisopropyl ether and dried in a desiccator under reduced pressure. 209 mg of compound are obtained. Mp=173-175° C.

1. customirradiated at 150° C. for 15 min
2. customThe organic phase is separated
3. customdried
4. concentrationconcentrated under reduced pressure
5. customA solid residue is obtained which
6. customis triturated in a mixture of 3 ml of dichloromethane and 3 ml of diisopropyl ether for 30 min
7. filtrationThe precipitate is recovered by filtration
8. washwashed with diisopropyl ether
9. customdried in a desiccator under reduced pressure