反应详情

4-Chloro-3-nitroquinoline (1.35 g, 6.48 mmol) and triethylamine (1.36 mL, 9.73 mmol) were sequentially added to a solution of (5-butylisoxazol-3-yl)methylamine (1.00 g, 6.48 mmol) in dichloromethane, and the solution was stirred for 48 hours at room temperature. The volatiles were removed under reduced pressure, and the residue was purified by flash column chromatography on silica gel (eluting with 3% methanol in dichloromethane) to provide 1.33 g of N-[(5-butylisoxazol-3-yl)methyl]-3-nitroquinolin-4-amine as a yellow, crystalline solid.

1. customThe volatiles were removed under reduced pressure
2. customthe residue was purified by flash column chromatography on silica gel (eluting with 3% methanol in dichloromethane)