HCID 67041255, compound → HCID 86247648, compound

HRID 606128Notes

Reaction equation

HRID 606128 reaction equation
[CH2:1]([C:5]1[O:9][N:8]=[C:7]([CH2:10][NH:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[CH:14][C:13]=2[N+:22]([O-])=O)[CH:6]=1)[CH2:2][CH2:3][CH3:4]>[Pt].C(#N)C>[CH2:1]([C:5]1[O:9][N:8]=[C:7]([CH2:10][NH:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=[CH:14][C:13]=2[NH2:22])[CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 67041255HCID 67041255, compound

Product 1

HCID 86247648HCID 86247648, compoundYield 98.4%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 6342AcetonitrileSolvent

Procedure

Catalytic 5% platinum on carbon (150 mg) was added to a suspension of N-[(5-butylisoxazol-3-yl)methyl]-3-nitroquinolin-4-amine (1.33 g, 4.08 mmol) in acetonitrile (50 mL), and the mixture was placed under hydrogen pressure (40 psi, 2.8×105 Pa) for six hours. The mixture was filtered through a layer of CELITE filter agent, and the filtrate was concentrated under reduced pressure to provide 1.19 g of N4-[(5-butylisoxazol-3-yl)methyl]quinoline-3,4-diamine.

Workup

  1. customfor six hours
  2. filtrationThe mixture was filtered through a layer of CELITE filter agent
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5ff0bd89ec1543af9241228ffa084f70
Source dataset
uspto-grants-2011_03
Patent number
US07915281B2

Reaction notes

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