Hydrazine hydrate (1:1) → HCID 23006268, compound

HRID 606131Notes

Reaction equation

HRID 606131 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[O:11][N:10]=[C:9]([CH2:12][N:13]3C(=O)C4C(=CC=CC=4)C3=O)[CH:8]=2)[CH:2]=1.O.NN>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[O:11][N:10]=[C:9]([CH2:12][NH2:13])[CH:8]=2)[CH:2]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 67041331HCID 67041331, compound

Product 1

HCID 23006268HCID 23006268, compound

Procedure

2-[(5-Pyridin-3-ylisoxazol-3-yl)methyl]-1H-isoindole-1,3(2H)-dione (2.95 g, 9.67 mmol) was treated with hydrazine hydrate (1.14 g, 19.3 mmol) according to the method described in Part E of Example 35 to provide (5-pyridin-3-ylisoxazol-3-yl)methylamine as a pale yellow solid.

Sources & evidence

ORD record
ord-38be3296b757407a85880a7b8048f44b
Source dataset
uspto-grants-2011_03
Patent number
US07915281B2

Reaction notes

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