HCID 67041341, compound → HCID 86247649, compound

HRID 606133Notes

Reaction equation

HRID 606133 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1[NH:14][CH2:15][C:16]1[CH:20]=[C:19]([C:21]3[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=3)[O:18][N:17]=1)=[CH:11][CH:10]=[CH:9][CH:8]=2)([O-])=O>[Pt]>[N:23]1[CH:24]=[CH:25][CH:26]=[C:21]([C:19]2[O:18][N:17]=[C:16]([CH2:15][NH:14][C:13]3[C:12]4[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=4)[N:6]=[CH:5][C:4]=3[NH2:1])[CH:20]=2)[CH:22]=1

Participants

3

Reactant 1

HCID 67041341HCID 67041341, compound

Product 1

HCID 86247649HCID 86247649, compoundYield 89.8%

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

3-Nitro-N-[(5-pyridin-3-ylisoxazol-3-yl)methyl]quinolin-4-amine (1.17 g, 3.37 mmol) was hydrogenated in the presence of 5% platinum on carbon (0.120 g) according to the method described in Part G of Example 35 to provide 0.96 g of N4-[(5-pyridin-3-ylisoxazol-3-yl)methyl]quinoline-3,4-diamine.

Sources & evidence

ORD record
ord-61948622bcc847f88115667097bccccf
Source dataset
uspto-grants-2011_03
Patent number
US07915281B2

Reaction notes

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