反应详情

After dissolving 3.00 g of 2,6-dichloropyrazine in 40 ml of tetrahydrofuran, 2.26 g of potassium tert-butoxide was added and the mixture was stirred for 5.5 hours at room temperature. The reaction solution was distilled off under reduced pressure, ethyl acetate was added to the residue and filtration was performed with NH silica gel and silica gel. The solvent was distilled off under reduced pressure to obtain the title compound (3.38 g, 90% yield).

1. additionwas added
2. distillationThe reaction solution was distilled off under reduced pressure, ethyl acetate
3. additionwas added to the residue and filtration
4. distillationThe solvent was distilled off under reduced pressure