反应详情

After dissolving 1.27 g of 1-(1-benzylpiperidin-4-yl)-2-(2-fluorophenyl)ethanone in 8 ml of 1,2-dichloroethane, 0.53 ml of 1-chloroethyl chloroformate was added while stirring on ice, and the mixture was heated to reflux for 1 hour. The solvent was distilled off under reduced pressure, 8 ml of methanol was added to the residue, and heating to reflux was continued for 40 minutes. The solvent was distilled off under reduced pressure, ethyl acetate was added to the residue, and the precipitate was filtered out to obtain the title compound (970 mg, 92% yield).

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureto reflux for 1 hour
4. distillationThe solvent was distilled off under reduced pressure, 8 ml of methanol
5. additionwas added to the residue
6. temperatureheating
7. temperatureto reflux
8. distillationThe solvent was distilled off under reduced pressure, ethyl acetate
9. additionwas added to the residue
10. filtrationthe precipitate was filtered out