反应详情

温度

0 °C

After dissolving 12.6 g of carbon tetrabromide in 80 ml of dichloromethane, the solution was cooled to 0° C. A 20 g portion of triphenylphosphine was added thereto in small portions at a time, and the mixture was stirred for 1 hour. A solution of 2.4 g of 2-fluorobenzaldehyde in dichloromethane (70 ml) was added dropwise and stirring was continued at 0° C. for 4 hours. After stirring overnight at room temperature, hexane was added and the mixture was filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate). The obtained 3.7 g of 1,1-dibromo-2-(2-fluorophenyl)ethene was dissolved in 30 ml of tetrahydrofuran, and the solution was cooled to −78° C. Next, 18 ml of n-butyllithium (1.6 M, n-hexane solution) was added dropwise. The mixture was stirred at −78° C. for 1 hour and then at room temperature for 1 hour. The obtained reaction solution was added dropwise to a solution of 2.6 g of tert-butyl 4-oxo-1-piperidinecarboxylate in tetrahydrofuran (100 ml) which had been cooled to −78° C. After stirring the mixture for 4 hours while slowly raising the temperature to room temperature, saturated aqueous ammonium chloride solution was added and extraction was performed with ethyl acetate. The organic layer was dried over magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate) to obtain the title compound (1.4 g, 23% yield, 2 steps).

1. stirringstirring
2. waitwas continued at 0° C. for 4 hours
3. stirringAfter stirring overnight at room temperature
4. filtrationthe mixture was filtered
5. concentrationThe filtrate was concentrated under reduced pressure
6. customthe residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate)
7. dissolutionThe obtained 3.7 g of 1,1-dibromo-2-(2-fluorophenyl)ethene was dissolved in 30 ml of tetrahydrofuran
8. temperaturethe solution was cooled to −78° C
9. additionNext, 18 ml of n-butyllithium (1.6 M, n-hexane solution) was added dropwise
10. stirringThe mixture was stirred at −78° C. for 1 hour
11. waitat room temperature for 1 hour
12. customThe obtained reaction solution
13. temperaturehad been cooled to −78° C
14. stirringAfter stirring the mixture for 4 hours
15. temperaturewhile slowly raising the temperature to room temperature
16. extractionextraction
17. dry with materialThe organic layer was dried over magnesium sulfate
18. distillationthe solvent was distilled off under reduced pressure
19. customThe residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate)