反应详情

After dissolving 517 mg of (1-benzylpiperidin-4-yl)-(1,3-dihydroisobenzofuran-1-yl)methanone in 5 ml of 1,2-dichloroethane, 0.49 ml of 1-chloroethyl chloroformate was added and the mixture was heated to reflux for 1 hour. The reaction solution was distilled off under reduced pressure, 5 ml of methanol was added to the residue and heating to reflux was continued for 1 hour. The reaction solution was distilled off under reduced pressure, saturated aqueous sodium bicarbonate solution was added and extraction was performed with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and then the solvent was distilled off under reduced pressure to obtain 104 mg of (1,3-dihydroisobenzofuran-1-yl)-(piperidin-4-yl)methanone hydrochloride.

1. additionwas added
2. temperaturethe mixture was heated
3. temperatureto reflux for 1 hour
4. distillationThe reaction solution was distilled off under reduced pressure, 5 ml of methanol
5. additionwas added to the residue
6. temperatureheating
7. temperatureto reflux
8. distillationThe reaction solution was distilled off under reduced pressure, saturated aqueous sodium bicarbonate solution
9. additionwas added
10. extractionextraction
11. dry with materialThe extract was dried over anhydrous magnesium sulfate
12. distillationthe solvent was distilled off under reduced pressure