反应详情

A suspension of 4-bromo-6-methoxy-3-methyl-2H-isoquinolin-1-one (9.3 g, 35 mmol) in POCl3 (50 ml) is refluxed for 1 h. After cooling to room temperature, POCl3 is removed. The residue is diluted with water (50 ml) and neutralized with saturated NaHCO3. The resulting solid is filtered and dried to give 9.8 g of 4-bromo-1-chloro-6-methoxy-3-methyl-isoquinoline. 1H NMR (CDCl3) 8.17 (d, 1H), 7.43 (s, 1H), 7.25 (d, 1H), 4.01 (s, 3H), 2.80 (s, 3H).

1. temperatureis refluxed for 1 h
2. customPOCl3 is removed
3. additionThe residue is diluted with water (50 ml)
4. filtrationThe resulting solid is filtered
5. customdried