Phosphorus oxychloride → 4-Bromo-1-chloro-6-methoxy-3-methylisoquinoline

Beteiligte Stoffe

Reaktionsschritte

A suspension of 4-bromo-6-methoxy-3-methyl-2H-isoquinolin-1-one (9.3 g, 35 mmol) in POCl3 (50 ml) is refluxed for 1 h. After cooling to room temperature, POCl3 is removed. The residue is diluted with water (50 ml) and neutralized with saturated NaHCO3. The resulting solid is filtered and dried to give 9.8 g of 4-bromo-1-chloro-6-methoxy-3-methyl-isoquinoline. 1H NMR (CDCl3) 8.17 (d, 1H), 7.43 (s, 1H), 7.25 (d, 1H), 4.01 (s, 3H), 2.80 (s, 3H).

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