反应详情

A mixture of 2′,4′-dihydroxy-propiophenone (24.9 g, 0.15 mol), 3-bromo-propyne (24.2 g, 0.20 mol) and K2CO3 (20.7 g, 0.15 mol) in acetone (500 mL) was refluxed for 12 h. The reaction mixture was allowed assume room temperature and the precipitate was removed by filtration. The filtrate was concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel, 0→2% MeOH in H2O), to give 26.2 g (85%) of 1-(2-hydroxy-4-prop-2-ynyloxy-phenyl)-propan-1-one.

1. temperaturewas refluxed for 12 h
2. customwas allowed assume room temperature
3. customthe precipitate was removed by filtration
4. concentrationThe filtrate was concentrated under reduced pressure
5. customThe crude product was purified by column chromatography (silica gel, 0→2% MeOH in H2O)