5,8-Difluoro-2H-chromene → 8-Bromo-6-fluoro-2H-chromene

HRID 606346Notes

Reaction equation

HRID 606346 reaction equation
FC1C=CC(F)=C2C=1C=CCO2.[Br:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[CH:16][C:15]=1[O:21][CH2:22][C:23]#[CH:24]>>[Br:13][C:14]1[CH:19]=[C:18]([F:20])[CH:17]=[C:16]2[C:15]=1[O:21][CH2:22][CH:23]=[CH:24]2

Participants

3

Reactant 2

HCID 224828145,8-Difluoro-2H-chromeneHCID 224828682-Bromo-4-fluoro-1-prop-2-ynyloxybenzene

Product 1

HCID 224827988-Bromo-6-fluoro-2H-chromeneYield 47%

Procedure

This compound was prepared analogously to 5,8-difluoro-2H-chromene but using (15 g, 65 mmol) of 2-bromo-4-fluoro-1-prop-2-ynyloxybenzene to give the title compound (7 g, 46%)

Sources & evidence

ORD record
ord-c60f706f8c1e435cadfbca877e9ceedd
Source dataset
uspto-grants-2011_03
Patent number
US07915295B2

Reaction notes

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