5-(4-Methanesulfinyl-phenoxy)-2-nitro-pyridine → HCID 59687009, compound

HRID 606366Notes

Reaction equation

HRID 606366 reaction equation
[CH3:1][S:2]([C:4]1[CH:19]=[CH:18][C:7]([O:8][C:9]2[CH:10]=[CH:11][C:12]([N+:15]([O-])=O)=[N:13][CH:14]=2)=[CH:6][CH:5]=1)=[O:3]>CCO.CCOC(C)=O.[Pd]>[CH3:1][S:2]([C:4]1[CH:19]=[CH:18][C:7]([O:8][C:9]2[CH:10]=[CH:11][C:12]([NH2:15])=[N:13][CH:14]=2)=[CH:6][CH:5]=1)=[O:3]

Participants

5

Reactant 1

HCID 596869915-(4-Methanesulfinyl-phenoxy)-2-nitro-pyridine

Product 1

HCID 59687009HCID 59687009, compoundYield 53%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

5-(4-Methanesulfinyl-phenoxy)-2-nitro-pyridine (1.27 g, 4.56 mmol) was dissolved in EtOH (30 ml) and EtOAc (8 ml). Pd/C (10%) (400 mg) was added and the nitro group was reduced to the amine by hydrogenation at atmospheric pressure for 3 h. The catalyst was filtered off and the filtrate was evaporated to give 0.6 g of 5-(4-Methanesulfinyl-phenoxy)-pyridin-2-ylamine.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-b0a4a2717e2249a28d05f820c2f61726
Source dataset
uspto-grants-2011_03
Patent number
US07915295B2

Reaction notes

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