反应详情

温度

100 °C

A mixture of ethyl 4-[({[4-oxo-2-({[(2-{[3-(1H-1,2,4-triazol-3-yl)propyl]oxy}pyridin-4-yl)methyl]amino}carbonyl)-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl]methyl}oxy)methyl]benzoate obtained in Example 41 (309 mg, 0.512 mmol), 4N aqueous sodium hydroxide solution (0.64 mL, 2.6 mmol), THF (6 mL), methanol (6 mL) and water (6 mL) was stirred at 100° C. for 2 hr. The reaction mixture was concentrated under reduced pressure, and 1N hydrochloric acid and methanol were added to the residue. The resulting crystals were recrystallized from ethyl acetate to give the title compound as a white powder (221 mg, 75%).

1. concentrationThe reaction mixture was concentrated under reduced pressure, and 1N hydrochloric acid and methanol
2. additionwere added to the residue
3. customThe resulting crystals were recrystallized from ethyl acetate