HCID 178468933, compound → HCID 178524389, compound

HRID 606407Notes

Reaction equation

HRID 606407 reaction equation
O=C1NC(C(NCC2C=CN=C(OCCCC3N=CNN=3)C=2)=O)=NC2SC=C(COCC3C=CC(C(OCC)=O)=CC=3)C1=2.[O:44]=[C:45]1[NH:50][C:49]([C:51](=[O:69])[NH:52][CH2:53][C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([O:60][CH2:61][CH2:62][O:63][C:64]3[N:68]=[CH:67][NH:66][N:65]=3)[CH:55]=2)=[N:48][C:47]2[S:70][CH:71]=[C:72]([CH2:73][O:74][CH2:75][C:76]3[CH:86]=[CH:85][C:79]([C:80]([O:82]CC)=[O:81])=[CH:78][CH:77]=3)[C:46]1=2>>[O:44]=[C:45]1[NH:50][C:49]([C:51](=[O:69])[NH:52][CH2:53][C:54]2[CH:59]=[CH:58][CH:57]=[C:56]([O:60][CH2:61][CH2:62][O:63][C:64]3[N:68]=[CH:67][NH:66][N:65]=3)[CH:55]=2)=[N:48][C:47]2[S:70][CH:71]=[C:72]([CH2:73][O:74][CH2:75][C:76]3[CH:77]=[CH:78][C:79]([C:80]([OH:82])=[O:81])=[CH:85][CH:86]=3)[C:46]1=2

Participants

3

Reactant 2

HCID 178468933HCID 178468933, compoundHCID 178468934HCID 178468934, compound

Product 1

HCID 178524389HCID 178524389, compound

Procedure

By a method similar to that in Example 42 and using, instead of ethyl 4-[({[4-oxo-2-({[(2-{[3-(1H-1,2,4-triazol-3-yl)propyl]oxy}pyridin-4-yl)methyl]amino}carbonyl)-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl]methyl}oxy)methyl]benzoate, ethyl 4-({[4-oxo-2-({3-[2-(1H-1,2,4-triazol-3-yloxy)ethoxy]benzyl}carbamoyl)-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl]methoxy}methyl)benzoate obtained in Example 49, the title compound was obtained as a white powder (419.2 mg, 80%).

Sources & evidence

ORD record
ord-9ad02558ecc1404d94eb771045ae4c21
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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