HCID 59298535, compound → HCID 178522986, compound

HRID 606409Notes

Reaction equation

HRID 606409 reaction equation
O=C1C2C(=CC=CC=2)N=C(C(OCC)=O)N1.[O:17]=[C:18]1[NH:23][C:22]([C:24]([O:26]CC)=O)=[N:21][C:20]2[S:29][CH:30]=[C:31]([C:32]3[CH:37]=[CH:36][N:35]=[CH:34][CH:33]=3)[C:19]1=2.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)N2C=NC(CCCOC3C=C(CN)C=CN=3)=N2)C=CC=CC=1.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:81]2[CH:85]=[N:84][C:83]([O:86][CH2:87][CH2:88][O:89][C:90]3[CH:91]=[C:92]([CH2:96][NH2:97])[CH:93]=[CH:94][CH:95]=3)=[N:82]2)C=CC=CC=1>>[O:17]=[C:18]1[NH:23][C:22]([C:24]([NH:97][CH2:96][C:92]2[CH:93]=[CH:94][CH:95]=[C:90]([O:89][CH2:88][CH2:87][O:86][C:83]3[N:84]=[CH:85][NH:81][N:82]=3)[CH:91]=2)=[O:26])=[N:21][C:20]2[S:29][CH:30]=[C:31]([C:32]3[CH:33]=[CH:34][N:35]=[CH:36][CH:37]=3)[C:19]1=2

Participants

5

Reactant 4

HCID 59298535HCID 59298535, compoundHCID 667687691-[2-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl}oxy)pyridin-4-yl]methanamineHCID 667690991-{3-[(2-([1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy)ethyl)oxy}phenyl]methanamineHCID 135437466Ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate

Product 1

HCID 178522986HCID 178522986, compound

Procedure

By a method similar to that in Example 22, and using, instead of ethyl 4-oxo-3,4-dihydro-2-quinazolinecarboxylate, ethyl 4-oxo-5-pyridin-4-yl-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate obtained in Reference Example 66 and using, instead of 1-[2-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl}oxy)pyridin-4-yl]methaneamine, 1-{3-[(2-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy}ethyl)oxy]phenyl}methanamine obtained in Reference Example 32, the title compound was obtained as a white powder (142.0 mg, 59%).

Workup

  1. customobtained in Reference Example 66
  2. customobtained in Reference Example 32

Sources & evidence

ORD record
ord-b24e8eb6123d4a39acef4bbf88990bc3
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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