Ethyl 4-[3-({[(5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)carbonyl]amino}methyl)phenoxy]butanoate → 4-[3-({[(5-Methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)carbonyl]amino}methyl)phenoxy]butanoic acid

HRID 606436Notes

Reaction equation

HRID 606436 reaction equation
O=C1NC(C(NCC2C=CN=C(OCCCC3N=CNN=3)C=2)=O)=NC2SC=C(COCC3C=CC(C(OCC)=O)=CC=3)C1=2.[CH3:44][C:45]1[C:53]2[C:52](=[O:54])[NH:51][C:50]([C:55]([NH:57][CH2:58][C:59]3[CH:60]=[C:61]([CH:71]=[CH:72][CH:73]=3)[O:62][CH2:63][CH2:64][CH2:65][C:66]([O:68]CC)=[O:67])=[O:56])=[N:49][C:48]=2[S:47][CH:46]=1>>[CH3:44][C:45]1[C:53]2[C:52](=[O:54])[NH:51][C:50]([C:55]([NH:57][CH2:58][C:59]3[CH:60]=[C:61]([CH:71]=[CH:72][CH:73]=3)[O:62][CH2:63][CH2:64][CH2:65][C:66]([OH:68])=[O:67])=[O:56])=[N:49][C:48]=2[S:47][CH:46]=1

Participants

3

Reactant 2

HCID 57708850Ethyl 4-[3-({[(5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)carbonyl]amino}methyl)phenoxy]butanoateHCID 178468934HCID 178468934, compound

Product 1

HCID 577088214-[3-({[(5-Methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)carbonyl]amino}methyl)phenoxy]butanoic acid

Procedure

By a method similar to that in Example 42 and using, instead of ethyl 4-[({[4-oxo-2-({[(2-{[3-(1H-1,2,4-triazol-3-yl)propyl]oxy}pyridin-4-yl)methyl]amino}carbonyl)-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl]methyl}oxy)methyl]benzoate, ethyl 4-[3-({[(5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)carbonyl]amino}methyl)phenoxy]butanoate obtained in Reference Example 122, the title compound was obtained as a white powder (465.7 mg, 91%).

Workup

  1. customobtained in Reference Example 122

Sources & evidence

ORD record
ord-aefd8866cf1b44c7b63ae130adb3431e
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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