HCID 59298384, compound → HCID 178522976, compound

HRID 606437Notes

Reaction equation

HRID 606437 reaction equation
O=C1C2C(=CC=CC=2)N=C(C(OCC)=O)N1.[C:17]1([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH:22]=[CH:21][C:20]([C:23]2[C:31]3[C:30](=[O:32])[NH:29][C:28]([C:33](OCC)=[O:34])=[N:27][C:26]=3[S:25][CH:24]=2)=[CH:19][CH:18]=1.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)N2C=NC(CCCOC3C=C(CN)C=CN=3)=N2)C=CC=CC=1.C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:87]2[CH:91]=[N:90][C:89]([O:92][CH2:93][CH2:94][O:95][C:96]3[CH:97]=[C:98]([CH2:102][NH2:103])[CH:99]=[CH:100][CH:101]=3)=[N:88]2)C=CC=CC=1>>[C:17]1([C:38]2[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=2)[CH:22]=[CH:21][C:20]([C:23]2[C:31]3[C:30](=[O:32])[NH:29][C:28]([C:33]([NH:103][CH2:102][C:98]4[CH:99]=[CH:100][CH:101]=[C:96]([O:95][CH2:94][CH2:93][O:92][C:89]5[N:90]=[CH:91][NH:87][N:88]=5)[CH:97]=4)=[O:34])=[N:27][C:26]=3[S:25][CH:24]=2)=[CH:19][CH:18]=1

Participants

5

Reactant 4

HCID 59298384HCID 59298384, compoundHCID 667687691-[2-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl}oxy)pyridin-4-yl]methanamineHCID 667690991-{3-[(2-([1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy)ethyl)oxy}phenyl]methanamineHCID 135437466Ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate

Product 1

HCID 178522976HCID 178522976, compound

Procedure

By a method similar to that in Example 22, and using, instead of ethyl 4-oxo-3,4-dihydro-2-quinazolinecarboxylate, ethyl 5-biphenyl-4-yl-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxylate obtained in Reference Example 136 and using, instead of 1-[2-({3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propyl}oxy)pyridin-4-yl]methaneamine, 1-{3-[(2-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy}ethyl)oxy]phenyl}methanamine obtained in Reference Example 32, the title compound was obtained as a white powder (155.4 mg, 85%).

Workup

  1. customobtained in Reference Example 136
  2. customobtained in Reference Example 32

Sources & evidence

ORD record
ord-0b27fdd206594ba0a5fa2c89aa84479d
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

Loading…