反应详情

温度

80 °C

A solution of 3-[(2-chloroethyl)oxy]benzonitrile obtained in Reference Example 1 (11.3 g, 62.3 mmol), 1H-1,2,4-triazole-3-thiol (6.00 g, 59.3 mmol) and triethylamine (8.40 mL, 62.3 mmol) in ethanol (50 mL) was stirred at 80° C. for 15 hr. The reaction mixture was concentrated under reduced pressure, and ethyl acetate and water were added to the residue. The organic layer was washed with saturated brine, dried over sodium sulfate, and concentrated to give the title compound as a white powder (14.4 g, 98%).

1. concentrationThe reaction mixture was concentrated under reduced pressure, and ethyl acetate and water
2. additionwere added to the residue
3. washThe organic layer was washed with saturated brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated