3-[(4-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]thio}butyl)oxy]benzonitrile → 1-{3-[(4-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]thio}butyl)oxy]phenyl}methanamine

HRID 606444Notes

Reaction equation

HRID 606444 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)N2C=NC(SCCCOC3C=C(C=CC=3)C#N)=N2)C=CC=CC=1.[C:38]1([C:44]([C:70]2[CH:75]=[CH:74][CH:73]=[CH:72][CH:71]=2)([C:64]2[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=2)[N:45]2[CH:49]=[N:48][C:47]([S:50][CH2:51][CH2:52][CH2:53][CH2:54][O:55][C:56]3[CH:57]=[C:58]([CH:61]=[CH:62][CH:63]=3)[C:59]#[N:60])=[N:46]2)[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1>>[C:64]1([C:44]([C:70]2[CH:75]=[CH:74][CH:73]=[CH:72][CH:71]=2)([C:38]2[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=2)[N:45]2[CH:49]=[N:48][C:47]([S:50][CH2:51][CH2:52][CH2:53][CH2:54][O:55][C:56]3[CH:57]=[C:58]([CH2:59][NH2:60])[CH:61]=[CH:62][CH:63]=3)=[N:46]2)[CH:69]=[CH:68][CH:67]=[CH:66][CH:65]=1

Participants

3

Reactant 2

HCID 667690813-[(4-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]thio}butyl)oxy]benzonitrileHCID 667691893-[(3-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]thio}propyl)oxy]benzonitrile

Product 1

HCID 667682581-{3-[(4-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]thio}butyl)oxy]phenyl}methanamine

Procedure

By a method similar to that in Reference Example 7 and using, instead of 3-[(3-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]thio}propyl)oxy]benzonitrile, 3-[(4-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]thio}butyl)oxy]benzonitrile obtained in Reference Example 10, the title compound was obtained as a yellow oil (8.65 g, 86%).

Workup

  1. customobtained in Reference Example 10

Sources & evidence

ORD record
ord-2b0571b767924271990ffdc76141cc19
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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