反应详情

温度

80 °C

A suspension of ethyl 4-[2-(aminocarbonothioyl)hydrazino]-4-oxobutanoate (16.8 g, 76.7 mmol) and sodium ethoxide (10.4 g, 153 mmol) in ethanol (200 mL) was stirred at 80° C. for 15 hr. The mixture was concentrated under reduced pressure, and the residue was acidified with 1N hydrochloric acid, and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, and concentrated to give the title compound as a white powder (14.0 g, 91%).

1. concentrationThe mixture was concentrated under reduced pressure
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with saturated brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated