methyl 1-trityl-1H-1,2,4-triazole-3-carboxylate → (1-trityl-1H-1,2,4-triazol-3-yl)methanol

HRID 606466Notes

Reaction equation

HRID 606466 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)N2C=NC(CCC(OCC)=O)=N2)C=CC=CC=1.[C:32]1([C:38]([C:54]2[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=2)([C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)[N:39]2[CH:43]=[N:42][C:41]([C:44](OC)=[O:45])=[N:40]2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[C:54]1([C:38]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)([C:48]2[CH:49]=[CH:50][CH:51]=[CH:52][CH:53]=2)[N:39]2[CH:43]=[N:42][C:41]([CH2:44][OH:45])=[N:40]2)[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=1

Participants

3

Reactant 2

HCID 58739241methyl 1-trityl-1H-1,2,4-triazole-3-carboxylateHCID 66769033ethyl 3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propanoate

Product 1

HCID 13471694(1-trityl-1H-1,2,4-triazol-3-yl)methanol

Procedure

By a method similar to that in Reference Example 26 and using, instead of ethyl 3-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]propanoate, methyl 1-(triphenylmethyl)-1H-1,2,4-triazole-3-carboxylate obtained in Reference Example 34, the title compound was obtained as a white powder (5.35 g, 58%).

Workup

  1. customobtained in Reference Example 34

Sources & evidence

ORD record
ord-f1a4c30d480a4073a812c8abfcb109ef
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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