反应详情

A solution of Intermediate 55b (1.72 g, 4.12 mmol) in THF (30 mL) was treated with LiAlH4 (2M in THF, 2.5 mL, 4.94 mmol) [CARE: gas evolution]. The reaction mixture was left to stir at RT for 5 h. The reaction was quenched slowly with water and the product was extracted with EtOAc. The organic phase was separated, washed with brine, dried over Na2SO4, and evaporated under reduced pressure to give the title compound (1.57 g, 95%). LCMS (Method 3): Rt 2.80 min, m/z 390 [MH+].

1. waitThe reaction mixture was left
2. customThe reaction was quenched slowly with water
3. extractionthe product was extracted with EtOAc
4. customThe organic phase was separated
5. washwashed with brine
6. dry with materialdried over Na2SO4
7. customevaporated under reduced pressure