反应详情

A suspension of 1-{3-[(3-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy}propyl)oxy]phenyl}methanamine obtained in Reference Example 85 (0.300 g, 0.611 mmol), ethyl 4-oxo-3,4-dihydro-2-quinazolinecarboxylate obtained according to the methods described in Journal of Organic Chemistry (1978), 43(23), 4485-7 and the like (0.133 g, 0.611 mmol) and N,N-diisopropylethylamine (0.213 mL, 1.22 mmol) in EtOH (4.5 mL) was stirred under microwave irradiation at 100° C. for 1.5 hr (Discover (trademark; CEM Corp), 50 W, run time: 5 min, hold time: 1.5 hr). After the reaction mixture was allowed to cool to room temperature, the precipitated solid was collected by filtration, and washed with EtOH to give the title compound as a white powder (0.315 g, 78%).

1. customobtained
2. filtrationthe precipitated solid was collected by filtration
3. washwashed with EtOH