Imidazole → 3-[3-(1H-imidazol-1-yl)propoxy]benzonitrile

HRID 606524Notes

Reaction equation

HRID 606524 reaction equation
ClCCOC1C=C(C=CC=1)C#N.Cl[CH2:14][CH2:15][CH2:16][O:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=1)[C:21]#[N:22].N1C=NC(S)=N1.[NH:32]1[CH:36]=[CH:35][N:34]=[CH:33]1>>[N:32]1([CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=2)[C:21]#[N:22])[CH:36]=[CH:35][N:34]=[CH:33]1

Participants

5

Reactant 4

HCID 795ImidazoleHCID 135691673-(2-Chloroethoxy)benzonitrileHCID 219940813-(3-Chloropropoxy)benzonitrileHCID 178527894HCID 178527894, compound

Product 1

HCID 432891803-[3-(1H-imidazol-1-yl)propoxy]benzonitrile

Procedure

By a method similar to that in Reference Example 2, and using, instead of 3-[(2-chloroethyl)oxy]benzonitrile, 3-[(3-chloropropyl)oxy]benzonitrile obtained in Reference Example 4 and using, instead of 1H-1,2,4-triazole-3-thiol, 1H-imidazole, the title compound was obtained as a colorless oil (1.65 g, 71%).

Workup

  1. customobtained in Reference Example 4

Sources & evidence

ORD record
ord-615527a5fbb4400b9ea48939d0d7afea
Source dataset
uspto-grants-2011_03
Patent number
US07915267B2

Reaction notes

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