反应详情

Isopropyl-thiourea (2.47 mmol) and 4-(2-Bromo-acetyl)-benzoic acid (2.47 mmol) were mixed in THF (12 mL). After stirring at room temperature for 5 minutes the mixture was heated to 80° C. for 2 hours. The volume was reduced to 5 mL and the mixture was then cooled to −20° C. and filtered. The solid was washed with a small amount of diethylether and dried. m/z=263.1 in MS ES+, which was characterized by hplc and MS and used in the next step without any further purification.

1. temperaturewas heated to 80° C. for 2 hours
2. temperaturethe mixture was then cooled to −20° C.
3. filtrationfiltered
4. washThe solid was washed with a small amount of diethylether
5. customdried
6. customused in the next step without any further purification