反应详情

Pyridin-2-yl-thiourea (2.06 mmol) and 4-(2-Bromo-acetyl)-benzoic acid (2.06 mmol) were mixed in THF (12 mL). After stirring at room temperature for 5 minutes the mixture was heated to 80° C. for 2 hours. The mixture was then cooled to room temperature and filtered. The solid was washed with a small amount of diethylether and dried. m/z=298.0 in MS ES+, which was characterized by hplc and MS and used in the next step without any further purification.

1. temperaturewas heated to 80° C. for 2 hours
2. temperatureThe mixture was then cooled to room temperature
3. filtrationfiltered
4. washThe solid was washed with a small amount of diethylether
5. customdried
6. customused in the next step without any further purification