3-(4-Fluoro-phenyl)-2-isopropyl-7,8-dihydro-2H-1,2,6-triaza-azulene-6-carboxylic acid benzyl ester → 3-(4-Fluoro-phenyl)-2-isopropyl-2,4,5,6,7,8-hexahydro-1,2,6-triaza-azulene

Participants

Reaction Steps

A mixture of 3-(4-fluoro-phenyl)-2-isopropyl-7,8-dihydro-2H-1,2,6-triaza-azulene-6-carboxylic acid benzyl ester (0.2 g, 0.49 mmol) and 10% Pd/C (20 mg) in isopropanol (20 mL) was subjected to H2 (45 psi) at rt for 16 h. The mixture was filtered and the filtrate was concentrated. The residue was purified by FCC to give the title compound.

Provenance & Evidence