HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 60669Generated: October 27, 2026
Diisopropylethylamine → HCID 117729390, compound
https://huagongshe.com/reaction/60669
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (1S,4R)-4-[3-((S)-2-Methyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-ylamine | HCID 86687106 | — |
| Reactant | {5-tert-Butyl-2-[2-(2-hydroxy-ethoxy)-pyridin-4-yl]-2H-pyrazol-3-yl}-carbamic acid 2,2,2-trichloro-ethyl ester | HCID 117729672 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 117729390 | HCID 117729390 | 84.6% |
Reaction Steps
Intermediate 67d (74 mg, 0.16 mmol) and Intermediate B (62 mg, 0.16 mmol) were suspended in 1,4-dioxane (5 mL) and DIPEA (32 mg, 42 μL, 0.25 mmol) added and the reaction heated to 60° C. for 18 h. The reaction was cooled, concentrated in vacuo and subjected to FCC, eluting with 0-5% 2M NH3 in MeOH/DCM, to afford the title compound (92 mg, 83%). LCMS (Method 3) Rt 3.51 min, 680.4 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09440974B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-93444e2e81ea41f696fc87f35e13e58b |
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| Source note | uspto-grants-2016_09 |
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