反应详情

Heat a solution of 5-bromo-2-fluorobenzoic acid (20 g, 92 mmol) and p-toluenesulfonic acid monohydrate (52 g, 275 mmol) in methanol (200 mL) at reflux overnight. Concentrate and dissolve the residue in ethyl acetate, wash twice with an aqueous saturated solution of sodium bicarbonate, once with an aqueous saturated solution of sodium chloride, dry (sodium sulfate), filter and concentrate to give the title compound as a clear liquid (19.7 g, 92%).

1. temperatureat reflux overnight
2. concentrationConcentrate
3. dissolutiondissolve the residue in ethyl acetate
4. washwash twice with an aqueous saturated solution of sodium bicarbonate, once with an aqueous saturated solution of sodium chloride
5. dry with materialdry (sodium sulfate)
6. filtrationfilter
7. concentrationconcentrate