反应详情

Add ethyl chloroformate (0.24 mL, 2.49 mmol) to a solution of 5-bromo-2-fluorobenzylamine hydrochloride (500 mg, 2.08 mmol) in dichloromethane (8 mL) and diisopropylethylamine (0.90 mL, 5.20 mmol). After 3 h dilute the reaction with diethyl ether and wash twice with 1 N hydrochloric acid and once with an aqueous saturated solution of sodium chloride. Dry (sodium sulfate), filter, and concentrate to give the title compound as a colorless oil (0.527 g, 92%).

1. additionAfter 3 h dilute
2. washwash twice with 1 N hydrochloric acid and once with an aqueous saturated solution of sodium chloride
3. dry with materialDry (sodium sulfate)
4. filtrationfilter
5. concentrationconcentrate