3-Iodopyridine → 3-(3,4-Difluorophenylethynyl)-pyridine

HRID 606851Notes

Reaction equation

HRID 606851 reaction equation
I[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[C:8]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[C:12]([F:17])[CH:11]=1)#[CH:9]>>[F:17][C:12]1[CH:11]=[C:10]([C:8]#[C:9][C:2]2[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=2)[CH:15]=[CH:14][C:13]=1[F:16]

Participants

3

Reactant 2

HCID 707143-IodopyridineHCID 138784543,4-Difluorophenylacetylene

Product 1

HCID 670476223-(3,4-Difluorophenylethynyl)-pyridineYield 21%

Procedure

Prepare essentially as described in EXAMPLE 46 using 3-iodopyridine (445 mg, 2.17 mmol) and 4-ethynyl-1,2-difluorobenzene, (prepared essentially as described in PREPARATION 14), (300 mg, 2.17 mmol) to give the title compound (87.6 mg, 21%).

Workup

  1. customPrepare essentially
  2. custom(prepared essentially
  3. customas described in PREPARATION 14), (300 mg, 2.17 mmol)

Sources & evidence

ORD record
ord-27867171597e4d74b16c6691679ff754
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

Loading…