3-Iodobenzonitrile → 3-(5-Methoxypyridin-3-ylethynyl)-benzonitrile

HRID 606853Notes

Reaction equation

HRID 606853 reaction equation
I[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].[C:10]([C:12]1[CH:13]=[N:14][CH:15]=[C:16]([O:18][CH3:19])[CH:17]=1)#[CH:11]>>[CH3:19][O:18][C:16]1[CH:17]=[C:12]([C:10]#[C:11][C:2]2[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=2)[C:5]#[N:6])[CH:13]=[N:14][CH:15]=1

Participants

3

Reactant 2

HCID 1443413-IodobenzonitrileHCID 210973493-Ethynyl-5-methoxypyridine

Product 1

HCID 670477103-(5-Methoxypyridin-3-ylethynyl)-benzonitrileYield 68%

Procedure

Prepare essentially as described in PREPARATION 10 using 3-iodobenzonitrile (681 mg, 3.0 mmol) and 3-ethynyl-5-methoxypyridine from PREPARATION 10 (415 mg, 3.1 mmol) at room temperature for 16 h to give the title compound (564 mg, 68%).

Workup

  1. customPrepare essentially

Sources & evidence

ORD record
ord-6756eadffaa94dacad88be5fc93406fc
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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