1-Ethynyl-4-fluorobenzene → HCID 67047602, compound

HRID 606856Notes

Reaction equation

HRID 606856 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[C:9]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)#[CH:10]>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]#[C:10][C:2]2[CH:3]=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 5226271-Ethynyl-4-fluorobenzeneHCID 8177133-Bromo-5-methylpyridine

Product 1

HCID 67047602HCID 67047602, compoundYield 25%

Procedure

Prepare essentially as described in PREPARATION 10 using 3-bromo-5-methylpyridine, (prepared as described in PREPARATION 1), (196 mg, 1.14 mmol) and 1-ethynyl-4-fluorobenzene (150 mg, 1.25 mmol) to give the title compound (60 mg, 25%).

Workup

  1. customPrepare essentially

Sources & evidence

ORD record
ord-5a57fa40d9334946884cbeded77ff887
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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