Benzene, 1-ethynyl-3-nitro- → 5-(3-Nitrophenylethynyl)-nicotinonitrile

HRID 606857Notes

Reaction equation

HRID 606857 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:9]=1)[C:7]#[N:8].[C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=1)#[CH:11]>>[N+:18]([C:14]1[CH:13]=[C:12]([C:10]#[C:11][C:2]2[CH:3]=[N:4][CH:5]=[C:6]([CH:9]=2)[C:7]#[N:8])[CH:17]=[CH:16][CH:15]=1)([O-:20])=[O:19]

Participants

3

Reactant 2

HCID 76432Benzene, 1-ethynyl-3-nitro-HCID 7367935-Bromonicotinonitrile

Product 1

HCID 670476845-(3-Nitrophenylethynyl)-nicotinonitrileYield 65%

Procedure

Prepare essentially as described in PREPARATION 10 using 5-bromonicotinonitrile (400 mg, 2.19 mmol) and 1-ethynyl-3-nitrobenzene, (prepared as described in PREPARATION 11), (644 mg, 4.38 mmol) to give the title compound (118 mg, 65%).

Workup

  1. customPrepare essentially

Sources & evidence

ORD record
ord-356cc2dc00924a26a34321e8a6467ac0
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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