Benzene, 1-iodo-3-(trifluoromethyl)- → 3-Methoxy-5-(3-trifluoromethyl-phenylethynyl)-pyridine

HRID 606858Notes

Reaction equation

HRID 606858 reaction equation
I[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:10])[F:9])[CH:3]=1.[C:12]([C:14]1[CH:15]=[N:16][CH:17]=[C:18]([O:20][CH3:21])[CH:19]=1)#[CH:13]>>[CH3:21][O:20][C:18]1[CH:17]=[N:16][CH:15]=[C:14]([C:12]#[C:13][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:10])[F:9])[CH:3]=2)[CH:19]=1

Participants

3

Reactant 2

HCID 67868Benzene, 1-iodo-3-(trifluoromethyl)-HCID 210973493-Ethynyl-5-methoxypyridine

Product 1

HCID 670483463-Methoxy-5-(3-trifluoromethyl-phenylethynyl)-pyridineYield 65%

Procedure

Prepare essentially as described in PREPARATION 10 using 1-iodo-3-trifluoromethylbenzene (0.430 mL, 3.0 mmol) and 3-ethynyl-5-methoxypyridine, (prepared essentially as described in PREPARATION 10), (415 mg, 3.1 mmol) at room temperature for 16 h to give the title compound (541 mg, 65%).

Workup

  1. customPrepare essentially
  2. custom(prepared essentially
  3. customas described in PREPARATION 10), (415 mg, 3.1 mmol) at room temperature for 16 h

Sources & evidence

ORD record
ord-621df7c6b98048b1818e8c5b574a7803
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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