HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 1-iodo-3-(trifluoromethyl)- → 3-Methoxy-5-(3-trifluoromethyl-phenylethynyl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 1-iodo-3-(trifluoromethyl)- | HCID 67868 | — |
| Reactant | 3-Ethynyl-5-methoxypyridine | HCID 21097349 | — |
| Product | 3-Methoxy-5-(3-trifluoromethyl-phenylethynyl)-pyridine | HCID 67048346 | 65% |
Reaction Steps
Prepare essentially as described in PREPARATION 10 using 1-iodo-3-trifluoromethylbenzene (0.430 mL, 3.0 mmol) and 3-ethynyl-5-methoxypyridine, (prepared essentially as described in PREPARATION 10), (415 mg, 3.1 mmol) at room temperature for 16 h to give the title compound (541 mg, 65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915424B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-621df7c6b98048b1818e8c5b574a7803 |
| Source note | uspto-grants-2011_03 |