3-Iodophenol → 5-(3-Hydroxyphenylethynyl)-nicotinonitrile

HRID 606861Notes

Reaction equation

I[C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[C:9]([C:11]1[CH:12]=[N:13][CH:14]=[C:15]([CH:18]=1)[C:16]#[N:17])#[CH:10]>>[OH:8][C:4]1[CH:3]=[C:2]([C:10]#[C:9][C:11]2[CH:12]=[N:13][CH:14]=[C:15]([CH:18]=2)[C:16]#[N:17])[CH:7]=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 122723-Iodophenol

HCID 224165635-Ethynylnicotinonitrile

Product 1

HCID 670475465-(3-Hydroxyphenylethynyl)-nicotinonitrileYield 17%

Procedure

Prepare essentially as described in EXAMPLE 10 using 3-iodophenol (0.69 g, 3.0 mmol) and 5-ethynylnicotinonitrile (0.4 g, 3.0 mmol) to give the title compound (110 mg, 17%).

Workup

customPrepare essentially

Sources & evidence

ORD record: ord-0aa0978605eb4a59b7d0246e7861106d
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07915424B2

Reaction notes

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