Ethanone, 1-(3-iodophenyl)- → 5-(3-Acetylphenylethynyl)-nicotinonitrile

HRID 606862Notes

Reaction equation

HRID 606862 reaction equation
I[C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.C[Si]([C:15]#[C:16][C:17]1[CH:18]=[N:19][CH:20]=[C:21]([CH:24]=1)[C:22]#[N:23])(C)C>>[C:8]([C:4]1[CH:3]=[C:2]([C:15]#[C:16][C:17]2[CH:18]=[N:19][CH:20]=[C:21]([CH:24]=2)[C:22]#[N:23])[CH:7]=[CH:6][CH:5]=1)(=[O:10])[CH3:9]

Participants

3

Reactant 2

HCID 84449Ethanone, 1-(3-iodophenyl)-HCID 161156995-[2-(Trimethylsilyl)ethynyl]pyridine-3-carbonitrile

Product 1

HCID 670477915-(3-Acetylphenylethynyl)-nicotinonitrileYield 49%

Procedure

Prepare according to the general procedure outlined in EXAMPLE 72 using 3′-iodoacetophenone (1.29 g, 5.24 mmol) and 5-trimethylsilanylethynyl-nicotinonitrile (1.0 g, 5.0 mmol), (prepared as described in PREPARATION 3), to give the title compound (600 mg, 49%).

Workup

  1. customPrepare

Sources & evidence

ORD record
ord-65e66405b9ed4a0ead069f51d7e3ef89
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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